Induction of apoptosis on breast adenocarcinoma and suppression of pathogenic bacterial growth by antioxidant rich tuber extract of Dioscorea Bulbifera

Nature derived product drew a lot of interest because their potential nutritional and therapeutics value. Most natural compounds are now processed developed as possible antioxidative, antimitotic, antimicrobial, anti-inflammatory, antiangiogenic, anti-carcinogenic pharmaceutical agents. Indeed, several products have been used lead in the development most potent physiologically relevant chemicals for therapeutic application. In current study antioxidant anticancer tuber extract Dioscorea bulbifera determined well its antimicrobial against pathogenic bacteria. The IC50 value was found to be 55µg/ml MCF-7 75µg/ml MD-AMB-231 human breast cancer adenocarcinoma whereas minimum inhibitory concentration (MIC) methanolic S. aureus 0.19 mg/ml bactericidal (MBC) 1.56 mg/ml. Further identify responsible antioxidant, activity GCMS analysis conducted. Histopathological haematological assay were carried out on animal model any toxic effect vital organ system. This may provide groundwork creation novel nature-derived drugs whose biological can by further purification, characterization, validation active phytochemicals mechanism action.